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SNDS — Medico-administrative data

Magellan

France's first private medico-administrative data infrastructure. From protocol to publication in 8 to 12 months. Built on the SNDS (CNIL Deliberation No. 2025-006 of 27 January 2022), data already extracted and structured. CNIL sandbox active since May 2021. Enriched by the Victoria pipeline and our phenotyping algorithms.

65M
SNDS beneficiaries
233
Selected variables (7–8% of SNDS)
10 yrs
Rolling window
7 months
vs 23 months standard pathway
Why Magellan

Three pillars, zero compromise

Real-world evidence in months, not years. The data is already extracted: after CESREES/CNIL approval, analyses start immediately.

Speed

SNDS data already extracted and structured by the Victoria pipeline. After CESREES/CNIL approval, no waiting for CNAM extraction: analyses start immediately.

7 months vs 23 months standard pathway
10-year rolling window
CNIL Deliberation No. 2025-006
No CNAM extraction to wait for

Coverage

99% of the French population covered. DCIR + PMSI + Covid vaccine data. 266 variables selected for maximum granularity, reduced to 161 variables (2–3%) in the Magellan data lake — privacy by design.

65M beneficiaries
266 selected variables
DCIR + PMSI + Covid vaccine
13 therapeutic areas covered

Compliance

Clinityx manages the entire regulatory pathway (CESREES, CNIL). Privacy by design: data minimisation, entropy control, inference risk control, noise injection ±10 patients. Only aggregated and anonymised indicators are delivered. Minimum threshold of 11 individuals per aggregate.

Variable minimisation (266 → 161)
Noise injection ±10 patients on all counts
Entropy and inference risk control
Min. threshold 11 individuals/aggregate
Time advantage

Evidence in months,
not years

Standard access to the SNDS takes approximately 23 months. With Magellan, data is already extracted and structured: after CESREES/CNIL approval, analyses start immediately without waiting for CNAM extraction.

Standard pathway

CESREES & CNIL
4 months
CNAM extraction
14 months
Analyses
5 months
Total duration 23 months

Magellan pathway

CESREES & CNIL
4 months
CNAM extraction
Immediate
Analyses
3 months
Total duration 7 months
-16 months
saved compared to the standard pathway — same regulatory steps, but data is already extracted and structured
Coverage & volume

A comprehensive view of care pathways

Magellan leverages SNDS data to provide national coverage of 65 million beneficiaries, with deep historical data and individual-level granularity.

Population covered

All beneficiaries of the general French health insurance scheme. Anonymised longitudinal data with individual follow-up.

65M beneficiaries

Historical depth

10-year rolling window of healthcare consumption. Longitudinal follow-up of patient pathways with continuous updates.

10 yrs rolling window

Pharmacy dispensations

All reimbursed drug dispensations (community and hospital). ATC classification, dosage, treatment duration, adherence.

100% of reimbursed dispensations

Hospitalisations (PMSI)

Public and private hospital stays via PMSI linkage. Primary and associated ICD-10 diagnoses, CCAM procedure codes.

PMSI individually linked

Long-Term Conditions

All active LTCs with ICD-10 diagnoses. Identification of chronic conditions and comorbidity tracking.

LTC ICD-10 diagnoses

Advanced phenotyping

Clinityx proprietary algorithms for cohort identification, treatment lines, comorbidity scores and care pathways. 266 variables selected from the SNDS, 161 in the Magellan data lake.

233 selected variables (7–8% of SNDS)
Available variables

Granular and longitudinal data

Magellan provides access to all SNDS reimbursement data flows, structured and enriched by our phenotyping algorithms.

Category Detail Available
Demographics Age, sex, region, municipality (IRIS), health insurance scheme, CMU-C, deprivation index ✓
Medications ATC 7 levels, INN, dosage, form, number of packs, dispensation date, prescriber ✓
Consultations General practitioner, specialist, act type, CCAM code, date, reimbursed amount ✓
Hospitalisations GHM, ICD-10 diagnoses (DP/DR/DAS), CCAM procedures, length of stay, facility type ✓
LTC & Pathologies ICD-10 codes for active LTCs, start date, identified chronic conditions ✓
Biology Medical biology acts (NABM codes), date and amount. No quantitative results. ✓
Medical devices LPP (list of products and services), delivery date, amount ✓
Phenotyping Clinityx proprietary algorithms: cohort identification, comorbidity scores, treatment lines ✓
Deaths Date of death (linked CepiDC), cause of death (when available) ✓
Privacy by design

Progressive data minimisation

Magellan applies a three-step data minimisation strategy, in line with privacy by design principles and CNIL recommendations.

Step 1: Variable selection
Magellan selects 266 variables from the ~3,000 available in the SNDS (7–8%). Only variables strictly necessary for analyses are extracted.
Step 2: Reduction in the data lake
The Magellan data lake reduces these 266 variables to 161 variables (2–3% of the SNDS). This reduction guarantees minimal access to raw data.
Step 3: Disclosure controls
Only aggregated and anonymised indicators are delivered. Minimum threshold of 11 individuals, noise injection ±10 patients on all counts, entropy and inference risk control.
Protection mechanisms
  • Variable minimisation: 266 → 161 variables
  • Noise injection: ±10 patients on all counts
  • Entropy control: verification of the quality of released data
  • Inference risk control: Prevention of re-identification
  • Disclosure threshold: Minimum 11 individuals per aggregate
  • CNIL sandbox: Active since May 2021, before final authorisation
Study capabilities

Robust observational studies

Magellan enables the full range of pharmacoepidemiological studies, from disease burden to post-listing studies.

Prevalence & incidence

Estimation of disease frequency at national scale. Temporal trends, regional variations.

Care pathways

Patient trajectory analysis: diagnostic delays, treatment sequences, switching, augmentation.

Disease burden

Economic and clinical burden of diseases. Direct costs, comorbidities, preventable hospitalisations.

Real-world effectiveness

Comparison of therapeutic strategies under real-world conditions. Propensity score, IPTW, survival analyses.

Safety & pharmacovigilance

Detection of safety signals. Treatment-associated risks, adverse events, active comparator design.

Health economics

Cost-effectiveness, budget impact, post-listing studies for HAS/CEPS dossiers and price negotiations.

Timeline

5 phases to accelerate your study

From protocol to manuscript, we manage every step with expertise and transparency.

1

Feasibility

Validation of the research question and available data.

2–4 wks

2

Protocol & Regulatory

Protocol writing and preparation of CNIL dossiers.

8–12 wks

3

SNDS extraction

Extraction and qualification of data from the SNDS.

4–6 wks

4

Statistical analysis

Data preparation and analyses according to the validated protocol.

8–12 wks

5

Report & Publication

Report writing and support for scientific publication.

4–6 wks

Completed studies

Concrete projects, published on Semaphore

Every Magellan study is documented on our transparency portal. Here are some examples of projects conducted on the Magellan EHR database.

Pulmonology — Boehringer Ingelheim

REPEAT — Real-world persistence of antifibrotic treatments

Study of antifibrotic treatment persistence in idiopathic pulmonary fibrosis. CNIL authorisation DR-2024-183.

Partner: Boehringer Ingelheim France
Cardiology — Edwards Lifesciences

Vitale — Transcatheter aortic valves

Assessment of long-term outcomes after transcatheter aortic valve implantation (TAVI) in the French population.

Partner: Edwards Lifesciences
Vaccination — Pfizer

Covid — Real-world vaccine follow-up

Analysis of vaccination coverage, vaccination schedules and post-vaccination follow-up for Covid-19 using SNDS data.

Partner: Pfizer
Medical devices

Mesh BSU — Sub-urethral slings

Medium-term quantification of the reoperation rate for complications and recurrence after BSU implantation across the entire French population.

Semaphore: Magellan Mesh — BSU →
Infrastructure

Victoria Pipeline

The processing engine that transforms raw SNDS data into structured, actionable variables. Peer-reviewed and published methodology.

Linearisation & cleaning

Deduplication, validation, management of DCIR/PMSI overlaps and billing splits.

Structured tables (7 entities)

Production of actionable entities: CCAM, ICD-10, LPP, Medications (with DDD), UM, Patients, Consultations, Biological Acts, LTC, GHM. 266 variables selected.

Integrated quality controls

4 families of automated cleaners. End-to-end auditable transformation chain. Validation on reference cohorts (70M Magellan patients).

Privacy by design

Data never leaves the secure enclave. Progressive minimisation: 233 → 161 variables. Maximum retention: 10-year rolling window.

Scientific publication

Victoria methodology published and peer-reviewed

SNDS processing pipeline for pharmacoepidemiological research. Published in the Journal of Health Informatics and indexed on PubMed.

DOI 10.1177/14604582251318250 · PubMed PMID 39913942
Data flow
CNAM SNDS Fils Victoria MAGELLAN

266 selected variables → 161 variables · Querying · Analytics · Aggregated indicators · Privacy by design

Victoria experience
France TAVI
50k patients
Fresh
2,500 patients
Rhea Fresh
1.5M patients
IC SNDS
3.5M patients
Magellan
70M patients
Technical architecture

From raw SNDS to clinical evidence

A secure 5-step pipeline, from data extraction to results delivery.

Step 01

CNAM extraction

Extraction of raw SNDS data via the permanent access authorised by the CNIL.

Step 02

Structuring

Victoria pipeline: cleaning, deduplication, linearisation and structuring into 266 actionable variables.

Step 03

Secure data lake

Storage on certified HDS infrastructure (cegedim.cloud). Pseudonymised data, restricted access.

Step 04

Minimised dataset

Extraction of a project-specific dataset. Only the variables required by the protocol are accessible.

Step 05

Results

Aggregated and anonymised indicators. Re-identification risk analysis at end of project to guarantee anonymity.

Regulatory framework

Secure and compliant access

Magellan is operated under permanent CNIL authorisation (Deliberation No. 2025-006). CNIL sandbox active since May 2021, before final authorisation. Each study has a dedicated protocol submitted to CESREES then to the CNIL, with patient information published via the Semaphore portal.

Deliberation No. 2025-006 (27/01/2022) HDS hosting Privacy by design Scientific committee Semaphore (transparency)
Scientific committee

Pr Mebazza (AP-HP) · Pr Zins (INSERM) · S. Combes (HDH) · Pr Gilard (CHU Brest) · and other independent experts

1

Feasibility

Assessment of the research question, cohort sizing, preliminary protocol.

2

CNIL declaration

Preparation of the authorisation request dossier with CESREES assessment then CNIL approval.

3

Transparency

Publication of the patient information notice on the Semaphore portal (Art. 14 GDPR).

4

Execution

Extraction, analysis and delivery of results in a secure HDS environment.

5

Delivery & archiving

Study report, statistical tables, compliant archiving. Support for scientific publication.

Differentiators

Magellan vs. standard SNDS access

Comparison between the Magellan pathway and standard SNDS access. Same regulatory scope, but a decisive time saving.

Criterion Magellan (Clinityx) Standard pathway
Time to results ~7 months ~23 months
CESREES / CNIL approval Required — managed by Clinityx Required — your responsibility
CNAM extraction Immediate — data already extracted 14 months
Pre-extracted & structured data ✓ 266 variables ✗
Automated pipeline (Victoria) ✓ Published & peer-reviewed ✗
Beneficiaries covered 65M (99% of population) 100% (if authorised)
Data window Rolling 10 years On request
French HDS hosting ✓ cegedim.cloud CASD / Other
Regulatory support ✓ End-to-end (CESREES, CNIL, Semaphore) Self-managed
Privacy by design ✓ Aggregated only (threshold 11) Access to individual data
Transparency portal ✓ Semaphore ✗
CNIL-authorised projects (2025) 35+ —

Launch your study
on Magellan

Contact our team to assess the feasibility of your project on the SNDS.

Request a feasibility assessment